The Complete ONCE Ingredient List: All 23 Actives and Why Each One Is There
ONCE contains 23 active ingredients in one 30-serving tub at $50 a month, including 5g creatine monohydrate, 5g collagen peptides, 600mg KSM-66 ashwagandha, 500mg microencapsulated NMN, 500mg lion's mane, 500mg vitamin C, 300mg magnesium glycinate, 250mg citicoline, 200mg L-theanine, 1g Ca-AKG, 750mg TMG and 10 billion CFU Bacillus coagulans. Zero caffeine. No proprietary blends.
This is the whole label. Every ingredient, every dose, every required form. No proprietary blends, because a proprietary blend exists to stop you doing exactly what this page lets you do.
The full panel
| Ingredient | Per serving | Required form and reason |
|---|---|---|
| Creatine monohydrate | 5 g | Micronized, so it disperses in cold water. Top of the studied range. |
| Collagen peptides | 5 g | Hydrolysed. Paired with the vitamin C synthesis requires. |
| Inulin | 1.5 g | Chicory root prebiotic. Feeds the Bacillus coagulans. |
| Taurine | 1 g | Cellular energy support. |
| Calcium alpha-ketoglutarate | 1 g | Krebs-cycle molecule. Carries about 190mg elemental calcium, declared. |
| Glycine | 1 g | Roughly a third of collagen's amino acid structure. Naturally sweet. |
| Betaine anhydrous (TMG) | 750 mg | Methyl donor. Pairs with the NMN. |
| KSM-66 ashwagandha | 600 mg | Root only, minimum 5% withanolides. The extract the cortisol trials used. |
| Lion's mane extract | 500 mg | Fruiting body, beta-glucan verified. Never mycelium grown on grain. |
| NMN, microencapsulated | 500 mg | Encapsulated so it survives an acidic powder and the shelf. |
| Vitamin C | 500 mg | Required cofactor for collagen synthesis. |
| Magnesium glycinate | 300 mg elemental | True bisglycinate, not oxide. |
| Citicoline | 250 mg | Stable choline form the body converts toward acetylcholine. |
| L-Theanine | 200 mg | Calm focus without sedation. |
| Hyaluronic acid | 120 mg | Low molecular weight, oral grade. |
| Vitamin D3 | 2,000 IU | Water-dispersible. Paired with K2. |
| Vitamin K2 (MK-7) | 120 mcg | Directs calcium correctly alongside the D3. |
| Zinc + Copper | 11 mg + 1 mg | Chelated, 11:1, because daily zinc depletes copper. |
| B-complex, all eight | 100%+ DV each | Methylated. Deliberately low-niacinamide. |
| Biotin | 500 mcg | Held low on purpose. Mega-doses interfere with blood tests. |
| Vitamin A (beta-carotene) & Vitamin E | 100% DV | Water-dispersible. |
| Bacillus coagulans | 10 B CFU | Spore form, with overage to guarantee CFU at expiry. |
| Iodine, Selenium, Chromium, Boron | 100% DV, 3 mg boron | Selenium as selenomethionine. |
| Sodium / Potassium | 150 / 200 mg | Light electrolytes. |
The interactions are the actual product
Any contract manufacturer can put 23 things in a tub. The formula is in how they sit together.
- Zinc balanced with copper at 11:1, because ongoing daily zinc depletes copper.
- D3 paired with K2 so absorbed calcium is directed correctly.
- B-complex specced low-niacinamide so it cannot blunt the NAD+ precursor sitting beside it.
- Selenium as selenomethionine so the 500mg of vitamin C does not interfere with it.
- Vitamin C included because collagen synthesis requires it.
- Inulin feeds the Bacillus coagulans. That pairing is a synbiotic, not two ingredients.
- No iron, which removes the classic iron, zinc and magnesium absorption fight.
- Fat-solubles present, which is why the directions say with breakfast.
What is deliberately not in it
- No caffeine. A daily you can only take before noon is not a daily.
- No proprietary blends. Every milligram is printed.
- No iron. It fights the minerals that are in here.
- No mega-dose biotin. 500mcg, for the blood-test reason above.
How to take it
ONCE launches as a 30-serving tub. One scoop into 12 to 16 ounces of cold water, stir, drink it with breakfast. That is the entire routine, and it costs $50 a month. There is no caffeine in it, so it works at 6am or 6pm.
Common questions
What is in ONCE?
ONCE contains 23 active ingredients per serving: 5g creatine monohydrate, 5g collagen peptides, 1.5g inulin, 1g taurine, 1g calcium alpha-ketoglutarate, 1g glycine, 750mg TMG, 600mg KSM-66 ashwagandha, 500mg lion's mane fruiting-body extract, 500mg microencapsulated NMN, 500mg vitamin C, 300mg elemental magnesium as glycinate, 250mg citicoline, 200mg L-theanine, 120mg hyaluronic acid, 2,000 IU vitamin D3, 120mcg vitamin K2 as MK-7, 11mg zinc with 1mg copper, a full methylated B-complex, 500mcg biotin, vitamins A and E, 10 billion CFU Bacillus coagulans, iodine, selenium, chromium, 3mg boron and light sodium and potassium electrolytes.
Does ONCE contain caffeine?
No. ONCE contains zero caffeine by design, so it can be taken at any hour of the day and stacks with coffee rather than competing with it.
Does ONCE use proprietary blends?
No. Every ingredient's milligram amount is printed on the label. Proprietary blends exist to conceal how little of each ingredient is present.
How do you take ONCE?
One scoop into 12 to 16 ounces of cold water, stirred, once daily with breakfast. Taking it with food matters because the formula contains fat-soluble vitamins A, D3, E and K2. ONCE launches as a 30-serving tub at $50 a month.
Why does ONCE contain no iron?
Iron competes with zinc and magnesium for absorption. Leaving it out removes that interaction, so the minerals that are in the formula are better absorbed.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is educational and is not medical advice; consult a physician before starting any supplement.